Dimethylformamide → HCID 58351063, compound

HRID 406314Notes

Reaction equation

HRID 406314 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])[C:6](O)=[O:7].CN(C)C=O.C(Cl)(=O)C([Cl:27])=O>O1CCCC1>[Cl:1][CH2:2][CH2:3][CH2:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])[C:6]([Cl:27])=[O:7]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 58351053HCID 58351053, compound

Product 1

HCID 58351063HCID 58351063, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Chloro-2-(2-trifluoromethylphenyl)valeric acid obtained in Preparation Example 2-3 (500 mg) was dissolved in tetrahydrofuran (9 mL). Dimethylformamide (0.1 ml) and oxalyl chloride (184 μL) were added at 0° C. and the reaction was initiated at room temperature. After 1.5 hours, concentration under reduced pressure gave an oil (532 mg), which was used directly for the next reaction as a crude product.

Workup

  1. customwas initiated at room temperature
  2. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-1629d6b52e374542904041cb768f83bd
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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