反应详情

温度

120 °C

To a solution of the tert-butyl (3S,5R)-1-(3-aminopyridin-4-yl)-5-methylpiperidin-3-ylcarbamate (1.0 eq) in 1,4-dioxane (0.067M) was added 2-(2,6-difluorophenyl)quinazolin-8-yl trifluoromethanesulfonate (1.0 eq), palladium acetate (0.2 eq), BINAP (1.5 eq), and cesium carbonate (3.0 eq). The reaction mixture was stirred at 120° C. for 10 min in microwave. The residue was dissolved in ethyl acetate (120 mL), and washed with water, brine, then dried over MgSO4, filtered, and evaporated under reduced pressure to give crude product, which was purified by column (ethyl acetate:hexanes=1:1 with 10% methanol) to yield tert-butyl (3S,5R)-1-(3-(2-(2,6-difluorophenyl)-quinazolin-8-ylamino)pyridin-4-yl)-5-methylpiperidin-3-ylcarbamate (79%). LC/MS (m/z): 547.1 (MH+), Rt=0.87

1. washwashed with water, brine
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customto give crude product, which
6. customwas purified by column (ethyl acetate:hexanes=1:1 with 10% methanol)