Triethylamine → HCID 15936310, compound

HRID 408960Notes

Reaction equation

HRID 408960 reaction equation
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8][C:7]=1[OH:16].C(N(CC)CC)C>C(OCC)C>[P:1]([Cl:5])([Cl:3])(=[O:2])[O:16][C:7]1[CH:8]=[CH:9][C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 86632-NaphtholHCID 24813Phosphorus oxychloride

Product 1

HCID 15936310HCID 15936310, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Phosphorus oxychloride (3.23 mL, 1 equiv) and β-naphthol (Aldrich, 5 g, 1 equiv) were stirred in anhydrous diethyl ether (25 mL). Anhydrous triethylamine was added (4.84 mL, 1 equiv) at −78° C. and the solution was allowed to warm to room temperature after 25 min. The triethylamine hydrochloride salt was filtered off and the solvent was removed under reduced pressure to give a clear pale yellow oil (7.95 g, 88%). (oil solidified in the freezer).

Workup

  1. filtrationThe triethylamine hydrochloride salt was filtered off
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-0024b03ef7c34b46bbce420be62f29af
Source dataset
uspto-grants-2014_06
Patent number
US08759318B2

Reaction notes

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