Triethylamine → HCID 86662557, compound

HRID 408962Notes

Reaction equation

HRID 408962 reaction equation
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[N:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([OH:16])[C:10]=2[CH:9]=[CH:8][CH:7]=1.C(N(CC)CC)C>C1COCC1>[P:1]([Cl:5])([Cl:3])(=[O:2])[O:16][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:10]=1[CH:9]=[CH:8][CH:7]=[N:6]2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24813Phosphorus oxychloride2×HCID 135441757Quinolin-5-ol

Product 1

HCID 86662557HCID 86662557, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Phosphorus oxychloride (0.385 mL, 4.14 mmol.) and quinolin-5-ol (Aldrich, 600 mg, 4.14 mmol.) were stirred in anhydrous THF (25 mL). Anhydrous triethylamine was added (0.576 mL, 4.14 mmol.) at −78° C. and the solution was allowed to warm to room temperature. The reaction mixture was monitored by 31PNMR for completion of phosphorus oxychloride (about 30 min) and this mixture was used directly.

Sources & evidence

ORD record
ord-296c5206d561476d8a6043062cb906b6
Source dataset
uspto-grants-2014_06
Patent number
US08759318B2

Reaction notes

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