Triethylamine → HCID 86662559, compound

HRID 408965Notes

Reaction equation

HRID 408965 reaction equation
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[CH3:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]=1[OH:17].C(N(CC)CC)C>C(OCC)C>[P:1]([Cl:5])([Cl:3])(=[O:2])[O:17][C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:15]=[CH:16][C:7]=1[CH3:6]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 240552-Methyl-1-naphtholHCID 24813Phosphorus oxychloride

Product 1

HCID 86662559HCID 86662559, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Phosphorus oxychloride (0.176 mL, 1 equiv) and 2-methylnaphthalen-1-ol (Aldrich, 0.3 g, 1 equiv) were stirred in anhydrous diethyl ether (10 mL). Anhydrous triethylamine was added (0.264 mL, 1 equiv) at −78° C. and stirred for 30 min. The dichloridate was very unstable at room temperature. The progress of the reaction was monitored by 31P NMR. This crude mixture was considered to be a 100% conversion to dichloridate and was used directly.

Workup

  1. customwas very unstable at room temperature

Sources & evidence

ORD record
ord-8a1f57cd883643e4b5a38d072ff529af
Source dataset
uspto-grants-2014_06
Patent number
US08759318B2

Reaction notes

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