Hydrochloric Acid → HCID 59662176, compound

HRID 409569Notes

Reaction equation

HRID 409569 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[C:21]([O:23][CH3:24])=[O:22])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C1(OC)C=CC=CC=1>O1CCOCC1>[CH3:24][O:23][C:21](=[O:22])[C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7519AnisoleHCID 59662171HCID 59662171, compound

Product 1

HCID 59662176HCID 59662176, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Compound 4-4 (40 mg, 0.11 mmol), dioxane (3 mL), 4N HCl in dioxane (3 mL) and a drop of anisole were added and stirred at rt for 2 hrs. The reaction mixture was concentrated, triturated with ether and dried in vacuo. Compound 4-5 was isolated as a white solid (33 mg, 100%). MS (ES+) m/z 253.7 (M+1).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customtriturated with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-1e7f5af3e8e0409cbf6f683754b054ce
Source dataset
uspto-grants-2014_06
Patent number
US08759342B2

Reaction notes

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