Methylamine → 2-Fluoro-4-(methylamino)-5-nitrobenzoic acid

HRID 410761Notes

Reaction equation

HRID 410761 reaction equation
[F:1][C:2]1[CH:10]=[C:9](F)[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:15][NH2:16]>C1COCC1>[F:1][C:2]1[CH:10]=[C:9]([NH:16][CH3:15])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 27828222,4-Difluoro-5-nitrobenzoic acid

Product 1

HCID 595298342-Fluoro-4-(methylamino)-5-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Fluoro-4-methylamino-5-nitro-benzoic acid (750 mg) was prepared by following General Procedure A starting from 2,4-difluoro-5-nitro-benzoic acid (1.0 g) and methylamine (2 M in THF, 2.46 mL) in THF.

Sources & evidence

ORD record
ord-23bfe7fce064480ca62974a04a9828e1
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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