Methylamine → 6-Methylamino-5-nitro-nicotinic acid ethyl ester

HRID 410795Notes

Reaction equation

HRID 410795 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8](Cl)=[N:7][CH:6]=1)[CH3:2].[CH3:16][NH2:17]>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([NH:17][CH3:16])=[N:7][CH:6]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 3784053Ethyl 6-chloro-5-nitronicotinate

Product 1

HCID 673333716-Methylamino-5-nitro-nicotinic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6-Methylamino-5-nitro-nicotinic acid ethyl ester (911 mg) was prepared by following General Procedure A starting from 6-chloro-5-nitro-nicotinic acid ethyl ester (1.0 g) and methylamine (2 M in THF, 3.25 mL) in DMF.

Sources & evidence

ORD record
ord-5f49cee6d57241138c910b2c2ab6a4d2
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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