Methylamine → 4-(Methylamino)-3-nitrobenzonitrile

HRID 410945Notes

Reaction equation

HRID 410945 reaction equation
C[C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:14][NH2:15]>CN(C=O)C>[CH3:14][NH:15][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[CH:2][C:9]=1[N+:10]([O-:12])=[O:11]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 673335284-Fluoro-2-methyl-3-nitrobenzonitrile

Product 1

HCID 46007154-(Methylamino)-3-nitrobenzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Methylamino-3-nitro-benzonitrile (1.69 mg) was prepared by following General Procedure A starting from methyl 4-fluoro-3-nitrobenzonitrile (1.66 g) and methylamine (2 M in THF, 10.0 mL) in DMF. The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-76818ce622944b4d8ce748b6f0782d42
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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