Methylamine → 1-[4-(Methylamino)-3-nitrophenyl]ethan-1-one

HRID 410952Notes

Reaction equation

HRID 410952 reaction equation
C[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)=[O:4].[CH3:15][NH2:16]>CN(C=O)C>[CH3:15][NH:16][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH3:2])=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 534295611-(4-Fluoro-3-nitrophenyl)propan-1-one

Product 1

HCID 131756261-[4-(Methylamino)-3-nitrophenyl]ethan-1-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1-(4-Methylamino-3-nitro-phenyl)-ethanone (153 mg) was prepared by following General Procedure A starting from methyl 1-(4-fluoro-3-nitro-phenyl)-ethanone (183 mg) and methylamine (2 M in THF, 1.0 ml) in DMF (5 mL). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-a17ca1bab8414d6b9c8a975d903ef7a1
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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