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HRID411014

反应详情

EQUATION

反应方程式

HRID 411014 的结构方程式

REACTANTS

反应物

4
结构：C[C@@H](O)C(=O)O
HCID61503

D-Lactic acid

C3H6O3

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CC(C)(C)OC(=O)N[C@@H]1CCNC1
HCID1514397

tert-Butyl (3R)-pyrrolidin-3-ylcarbamate

C9H18N2O2

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID2733084

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

C11H16F6N5OP

PRODUCTS

生成物

1
结构：C[C@@H](O)C(=O)N1CC[C@@H](NC(=O)OC(C)(C)C)C1
HCID67334983

未命名化合物

收率 96.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

[(R)-1-((R)-2-Hydroxy-propionyl)-pyrrolidin-3-yl]carbamic acid tert-butyl ester (500 mg) was prepared by following General Procedure F starting from (R)-2-hydroxy-propionic acid (200 mg), (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester (372 mg), HBTU (800 mg), and DIEA (400 uL) in DMF (4 mL).