1,2-Dichloroethane → HCID 63261691, compound

HRID 412062Notes

Reaction equation

HRID 412062 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C@H:12]([CH2:20][OH:21])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>C(Cl)Cl.C(N(CC)CC)C>[C:14]1([CH2:13][CH:12]([NH:11][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[N:10][C:2]=2[Cl:1])[CH2:20][OH:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 762582-Chloronicotinic acidHCID 447213phenylalaninol, (S)-

Product 1

HCID 63261691HCID 63261691, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

10.0 g of chloronicotinic acid were reacted with 9.7 g of phenylalaninol in 250 ml of CH2Cl2 in the presence of 13.0 g of EDC, 2.9 g of HOBT and 9.6 g of triethylamine analogously to Example 1c, 17.3 g (94%) of the product being obtained.

Workup

  1. custombeing obtained

Sources & evidence

ORD record
ord-17ac732af2e14de7bdb33eddb3349769
Source dataset
uspto-grants-2003_05
Patent number
US06562827B1

Reaction notes

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