Potassium Carbonate → 18-Crown-6

HRID 412063Notes

Reaction equation

HRID 412063 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=CC=CC=1CN1CCNCC1.[C:16](=[O:19])([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]1[O:2][CH2:3][CH2:15][O:19][CH2:16][CH2:1][O:2][CH2:3][CH2:15][O:19][CH2:16][CH2:1][O:2][CH2:3][CH2:15][O:19][CH2:16]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 5781921-(2-Methoxybenzyl)piperazine

Product 1

HCID 2855718-Crown-6

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.0 g of intermediate compound 8a were reacted in 70 ml of DMF with 2.9 g of N-(2-methoxybenzyl)piperazine analogously to Example 8b in the presence of 5.7 g of potassium carbonate and a spatula tipful of 18-crown-6, 1.3 g (27%) of the product being obtained.

Sources & evidence

ORD record
ord-df73b472d38549b88c863505e8777eea
Source dataset
uspto-grants-2003_05
Patent number
US06562827B1

Reaction notes

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