Potassium Carbonate → 18-Crown-6

HRID 412064Notes

Reaction equation

HRID 412064 reaction equation
ClC1N=CC=C[C:3]=1[C:4]([O:6][CH3:7])=O.[C:12](=[O:15])([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:7]1[O:6][CH2:4][CH2:3][O:15][CH2:12][CH2:7][O:6][CH2:4][CH2:3][O:15][CH2:12][CH2:7][O:6][CH2:4][CH2:3][O:15][CH2:12]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 819931Methyl 2-chloronicotinate

Product 1

HCID 2855718-Crown-6

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3.4 g of methyl 2-chloronicotinate were reacted with 3.4 g of 4-piperidinopideridine in 75 ml of DMF in the presence of 5.5 g of potassium carbonate and a spatula tipful of 18-crown-6 analogously to Example 1a, 5.9 g (97%) of the product being obtained.

Sources & evidence

ORD record
ord-479e1379c7174a21a6b27c0e17ecb0a0
Source dataset
uspto-grants-2003_05
Patent number
US06562827B1

Reaction notes

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