Triethylamine → HCID 70029060, compound

HRID 412067Notes

Reaction equation

HRID 412067 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][CH:20]=[CH:19][C:15]=2[C:16]([OH:18])=O)[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[NH2:30][C@H:31]([CH2:39][OH:40])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C1C=CC2N(O)N=NC=2C=1>C(Cl)Cl.C(Cl)CCl>[C:33]1([CH2:32][CH:31]([NH:30][C:16](=[O:18])[C:15]2[CH:19]=[CH:20][CH:21]=[N:22][C:14]=2[N:11]2[CH2:10][CH2:9][N:8]([C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:7])[CH2:13][CH2:12]2)[CH2:39][OH:40])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 447213phenylalaninol, (S)-HCID 18536280HCID 18536280, compound

Product 1

HCID 70029060HCID 70029060, compound

Reagents, catalysts & solvents 2

HCID 111,2-DichloroethaneSolventHCID 6344DichloromethaneSolvent

Procedure

13 g of 2-(4-butoxycarbonylpiperazin-1-yl)nicotinic acid were dissolved in 150 ml of methylene chloride and 14.7 ml of triethylamine analogously to Example 1c and treated successively with 6.4 g of phenylalaninol, 1.9 g of HOBT and 8.11 g of EDC, 16.7 g (90%) of the product being obtained.

Workup

  1. custombeing obtained

Sources & evidence

ORD record
ord-a2a3b0c2b53642a285a963d80a2e3fbf
Source dataset
uspto-grants-2003_05
Patent number
US06562827B1

Reaction notes

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