Hydrochloric Acid → HCID 18536011, compound

HRID 412154Notes

Reaction equation

HRID 412154 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:20]([O:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][C:6]1=[O:18].[ClH:28]>C(OCC)(=O)C>[ClH:28].[Br:1][C:2]1[CH:22]=[CH:21][C:20]([O:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][C:6]1=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18536070HCID 18536070, compound

Product 1

HCID 18536011HCID 18536011, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Through a solution of the product from Step D (7.71 g, 16.6 mmol) in 100 mL of ethyl acetate at 0° C. was bubbled anhydrous HCl gas for 10 minutes. After 30 minutes, the solution was concentrated in vacuo to provide the titled salt as a white foam which was used in the next reaction without further purification.

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-91f24bc3f2414c5e9632f67c619718f9
Source dataset
uspto-grants-2003_05
Patent number
US06562823B1

Reaction notes

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