反应详情

A mixture of 5-[4-[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione dihydrochloride (288 mg), 4-nitrophenyl isocyanate (98 mg), triethylamine (121 mg), anhydrous tetrahydrofuran (10 ml) and anhydrous N,N-dimethylformamide (10 ml) was stirred at room temperature for 23 hours. The reaction mixture was concentrated and diluted with water. The precipitate was isolated by filtration and then chromatographed on a silica gel column using ethyl acetate as the eluant to afford the title compound (182 mg, mp 178-180° C.).

1. concentrationThe reaction mixture was concentrated
2. additiondiluted with water
3. customThe precipitate was isolated by filtration
4. customchromatographed on a silica gel column