反应详情

温度

80 °C

To a solution of 7-methoxy-2-trifluoromethanesulfonyloxynaphthalene (2.23 g) in dimethylformamide (8.9 ml) were added zinc cyanide (598 mg) and tetrakis(triphenylphosphine) palladium (337 mg) at room temperature, and the mixture was stirred at 80° C. for 1 hour. After completion of the reaction, water and ethyl acetate were added and insoluble material was removed. The organic layer was separated and concentrated, and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1) and dried under reduced pressure to give the title compound (965 mg).

1. additionwere added
2. custominsoluble material was removed
3. customThe organic layer was separated
4. concentrationconcentrated
5. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=19:1)
6. customdried under reduced pressure