反应详情

To a solution of 4-benzyloxyphenol (18.34 g) in tetrahydrofuran (150 ml) was added 60% sodium hydride (4.76 g) with ice-cooling, and the mixture was stirred at the same temperature for 15 min. Ethyl bromoacetate (14.2 ml) was added dropwise, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, 5% hydrochloric acid was added and the mixture was extracted with hexane. The extract was dried over anhydrous magnesium sulfate. The solvent was evaporated and the obtained solid was filtrated with hexane and dried under reduced pressure to give the title compound (21.78 g) as a white solid.

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 16 hours
3. additionwas added
4. extractionthe mixture was extracted with hexane
5. dry with materialThe extract was dried over anhydrous magnesium sulfate
6. customThe solvent was evaporated
7. filtrationthe obtained solid was filtrated with hexane
8. customdried under reduced pressure