Hydrochloric Acid → HCID 18538839, compound

HRID 412952Notes

Reaction equation

HRID 412952 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]([C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[CH:31]=2)[CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].Cl>CO.C(OCC)(=O)C>[ClH:36].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([N:12]([C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([Cl:37])[CH:31]=2)[CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([CH2:22][C:23]3[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=3)[CH2:20][CH2:21]2)=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 3013684HCID 3013684, compound

Product 1

HCID 18538839HCID 18538839, compoundYield 181.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

The title compound of example 17 (1096 mg) dissolved in methanol was treated with 4N hydrogen chloride solution in ethyl acetate (0.75 mL) and the solvent was removed under reduced pressure. Diethyl ether was added to the residue, the resulting precipitate was collected by filtration, washed with diethyl ether, and dried under reduced pressure to afford the title compound (1060 mg) as a white amorphous solid.

Workup

  1. customthe solvent was removed under reduced pressure
  2. additionDiethyl ether was added to the residue
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with diethyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-5b78fb1d372a45e281096af6308da24f
Source dataset
uspto-grants-2003_05
Patent number
US06562978B1

Reaction notes

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