Water → HCID 15739781, compound

HRID 413326Notes

Reaction equation

HRID 413326 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.C(N(CC)CC)C.Br[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7666Phenethyl bromideHCID 8471TriethylamineHCID 127654-Methoxybenzenethiol

Product 1

HCID 15739781HCID 15739781, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4-methoxy-benzene thiol (5.7 g), triethylamine (4.1 g) and 2-bromoethylbenzene (5.6 ml) in DMF (50 ml) at 0° C. was stirred for 2 h, then added to water and extracted with ether. The solvent was washed with water, 1M NaOH and brine, then dried and evaporated to give the title compound as colourless oil (8.9 g, 95%).

Workup

  1. extractionextracted with ether
  2. washThe solvent was washed with water, 1M NaOH and brine
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-f401f524186a42fd9d7ccd3b29d09277
Source dataset
uspto-grants-2003_05
Patent number
US06566384B1

Reaction notes

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