Ethyl ketone → 7,7,7-Trifluoro-3-ethyl-3-heptanol

1.3 g of magnesium, 10.0 g of 1-bromo-4,4,4-trifluorobutane and 20 g of tetrahydrofuran were added to a four-necked flask equipped with a nitrogen feeding pipe, a reflux condenser, a dropping funnel and a thermometer, and a Grignard reagent was prepared by a conventional method. Then, a mixture containing 5.0 g of 3-pentanone and 4 g of tetrahydrofuran was dropwise added to the obtained Grignard reagent at a temperature of 25 to 35° C. over 30 minutes, followed by stirring at the same temperature for 1 hour. The reaction mixture was treated by a conventional method, and the resulting organic phase was washed with water, followed by drying with anhydrous magnesium sulfate. Thereafter, the resultant was concentrated under reduced pressure, thereby obtaining 7.9 g of 7,7,7-trifluoro-3-ethyl-3-heptanol in the form of a pale yellow oily matter.

1. customequipped with a nitrogen feeding pipe, a reflux condenser, a dropping funnel
2. additionThe reaction mixture was treated by a conventional method
3. washthe resulting organic phase was washed with water
4. dry with materialby drying with anhydrous magnesium sulfate
5. concentrationThereafter, the resultant was concentrated under reduced pressure

ORD record

ord-606d302f54874402afc4c8a6e2f4cb8d

Source dataset

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08530598B2