Glutaric anhydride → HCID 4150750, compound

HRID 413704Notes

Reaction equation

HRID 413704 reaction equation
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH2:9][CH2:10][CH2:11][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>O1CCOCC1>[O:15]1[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][NH:9][C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 7940Glutaric anhydrideHCID 4082852-Morpholinoethylamine

Product 1

HCID 4150750HCID 4150750, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

There are added to 10 cm3 of dioxane, 1.517 g of glutaric anhydride and then, dropwise, 1.75 cm3 of N-(2-aminoethyl)morpholine. Stirring is continued at 20° C. for 0.75 hours. The white solid formed is filtered, washed successively with dioxane and diethyl ether, and then dried at 20° C. (90 Pa) to give 1.94 g of 5-(2-morpholinoethylamino)-5-oxopentanoic acid in the form of a white solid melting at 96° C.

Workup

  1. customThe white solid formed
  2. filtrationis filtered
  3. washwashed successively with dioxane and diethyl ether
  4. customdried at 20° C. (90 Pa)

Sources & evidence

ORD record
ord-c9917337ee64483996912ea0992efac7
Source dataset
uspto-grants-2003_05
Patent number
US06569854B1

Reaction notes

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