反应详情

温度

70 °C

Benzyl bromide (8.6 ml) was added to a stirred solution of 3-methoxysalicylaldehyde (10 g), potassium carbonate (14.76 g) and potassium iodide (0.12 g) in DMF (120 ml) under an atmosphere of argon. The reaction was heated at 70° C. for 16 hours. Water (200 ml) was added causing the precipitation of a brown oil which crystallised on cooling. The solid was filtered, washed with water, dissolved in dichloromethane and dried (MgSO4). The solvent was removed in vacuo to give an oil which crystallised on trituration with iso-hexane to give the product as an off white solid (12.85 g, 81%); NMR d (CD3SOCD3) 3.91 (s, 3H), 5.15 (s, 2H), 7.14-7.22 (m, 2H), 7.29-7.42 (m, 6H), 10.10 (t, 1H); M/z (+) 243 (MH+).

1. customthe precipitation of a brown oil which
2. customcrystallised
3. temperatureon cooling
4. filtrationThe solid was filtered
5. washwashed with water
6. dissolutiondissolved in dichloromethane
7. dry with materialdried (MgSO4)
8. customThe solvent was removed in vacuo
9. customto give an oil which
10. customcrystallised on trituration with iso-hexane