反应详情

A mixture of freshly distilled N-methylaniline (116 g, 1.1 mol), potassium carbonate (175 g, 1.25 mol), sodium iodide (4 g, 0.025 mol), 2-[2-(2-chloroethoxy)ethoxy]ethanol (168 g, 1 mol), and 900 mL of butanol was heated at reflux for 72 hours under nitrogen with vigorous stirring. After cooling and filtration the butanol was evaporated at reduced pressure to leave a tan oil. The oil was fractionally distilled in vacuo, yielding 150 g (63%) as a colorless oil, bp 190°-191° C. (0.13 mm).

1. temperaturewas heated
2. temperatureat reflux for 72 hours under nitrogen with vigorous stirring
3. temperatureAfter cooling
4. filtrationfiltration the butanol
5. customwas evaporated at reduced pressure
6. customto leave a tan oil
7. distillationThe oil was fractionally distilled in vacuo
8. customyielding 150 g (63%) as a colorless oil, bp 190°-191° C. (0.13 mm)