反应详情

温度

50 °C

A mixture of 4 g of O-benzylhydroxylamine, 4.28 g of benzyl bromide, and 12 g of K2CO3 in 50 ml of ethanol was stirred at 50° C. overnight. After removal of organic solvent, water was added to the residue and the mixture was then extracted with ethyl acetate. The combined extracts were dried and evaporated to give 4 g of crude product. Purification by dry column chromatography gave 1.8 g of oily product.

1. customAfter removal of organic solvent, water
2. additionwas added to the residue
3. extractionthe mixture was then extracted with ethyl acetate
4. customThe combined extracts were dried
5. customevaporated
6. customto give 4 g of crude product
7. customPurification
8. customby dry column chromatography