Phenylacetaldehyde → HCID 53844222, compound

HRID 414494Notes

Reaction equation

HRID 414494 reaction equation
[C:1]1([CH2:7][CH:8]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:11]([O:18][NH2:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:11]([O:18][N:19]=[CH:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 998PhenylacetaldehydeHCID 11430Potassium CarbonateHCID 102312Benzyloxyamine hydrochloride

Product 1

HCID 53844222HCID 53844222, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5 g of phenylacetaldehyde, 6.7 g of O-benzylhydroxylamine hydrochloride, and 3 g of potassium carbonate in 30 ml of aqueous methanol (1:1) was refluxed for 2 hours. The aqueous solution was extracted with ethyl acetate and the organic solution was dried and evaporated to give 8 g of crude product which was used without purification.

Workup

  1. temperaturewas refluxed for 2 hours
  2. extractionThe aqueous solution was extracted with ethyl acetate
  3. customthe organic solution was dried
  4. customevaporated

Sources & evidence

ORD record
ord-009a3675a0c945c2ad86344464a09c1b
Source dataset
uspto-grants-1988_12
Patent number
US04792560

Reaction notes

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