Hydrochloric Acid → HCID 131729333, compound

HRID 414912Notes

Reaction equation

HRID 414912 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][C:11](=[O:34])[CH2:12][CH2:13][CH2:14][C:15]([NH:17][CH:18]2[CH2:23][CH2:22][C:21]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)([N:24]([CH3:26])[CH3:25])[CH2:20][CH2:19]2)=[O:16])=[CH:4][CH:3]=1.Cl.Cl[Si](C)(C)C.C(OC(C)C)(C)C>CC(=O)CC.O.CO.C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][NH:10][C:11](=[O:34])[CH2:12][CH2:13][CH2:14][C:15]([NH:17][CH:18]2[CH2:19][CH2:20][C:21]([CH2:27][C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)([N:24]([CH3:26])[CH3:25])[CH2:22][CH2:23]2)=[O:16])=[CH:6][CH:7]=1

Participants

9

Reactant 4

HCID 313Hydrochloric AcidHCID 6397ChlorotrimethylsilaneHCID 7914Diisopropyl EtherHCID 131729334HCID 131729334, compound

Product 1

HCID 131729333HCID 131729333, compound

Reagents, catalysts & solvents 4

HCID 887MethanolSolventHCID 962WaterSolventHCID 6569Methyl Ethyl KetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

As described for Example 347, 335 mg of the polar diastereoisomer of glutaric acid (4-benzyl-4-dimethylaminocyclohexyl)amide [2-(4-chlorophenyl)ethyl]amide were obtained, which, dissolved in 30 ml 2-butanone, 30 ml ethyl acetate and 2 ml methanol, were converted into the corresponding hydrochloride by adding 12.5 μl water, 88 μl chlorotrimethylsilane and 10 ml diisopropylether (255 mg of white solid).

Workup

  1. customwere obtained

Sources & evidence

ORD record
ord-efdac79d9e85466aab33908556b76c57
Source dataset
uspto-grants-2012_01
Patent number
US08088763B2

Reaction notes

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