反应详情

To a solution of methyl 3-(4-isobutyrylpiperazine-1-carbonyl)benzoate (1.25 g, 3.9 mmol) in water (10 mL) and tetrahydrofuran (10 mL) at 0° C., lithium hydroxide monohydrate (250 mg, 6 mmol) was added. The mixture was stirred at that temperature for 2 h. The resulting mixture was neutralized to pH=5 with hydrochloric acid, and extracted with ethyl acetate (100 mL×4) and concentrated to obtain a white solid of 3-(4-isobutyrylpiperazine-1-carbonyl)benzoic acid (1.1 g, yield 76%). LC-MS (ESI) m/z: 305 (M+1)+.

1. extractionextracted with ethyl acetate (100 mL×4)
2. concentrationconcentrated