反应详情

Under atmosphere of argon, to a solution of 4-methylthiazol-2-sulfonyl chloride in methyl t-butyl ether (0.20 M, 20 ml), 1-hydroxybenzotriazole (549 mg) and triethylamine (0.57 ml) were added under stirring with cooled on ice bath, and the mixture was stirred for 1 hour at room temperature. To the reaction mixture, ethyl acetate was added. The organic layer was washed with water three times, with a saturated aqueous solution of sodium chloride once successively, dried over an anhydrous magnesium sulfate and concentrated to give the compound of the present invention (1.1 g) having the following physical data.

1. temperaturewith cooled on ice bath
2. stirringthe mixture was stirred for 1 hour at room temperature
3. washThe organic layer was washed with water three times, with a saturated aqueous solution of sodium chloride once successively
4. dry with materialdried over an anhydrous magnesium sulfate
5. concentrationconcentrated
6. customto give the compound of the present invention (1.1 g)