Benzyl Bromide → HCID 59180346, compound

HRID 416112Notes

Reaction equation

[F:1][C:2]1[CH:14]=[C:13]([CH2:15][CH2:16][CH:17]([OH:33])[C:18]2[S:19][C:20]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[CH:21][CH:22]=2)[CH:12]=[CH:11][C:3]=1[O:4][CH:5]([CH2:9][CH3:10])[C:6]([OH:8])=[O:7].[H-].[Na+].[CH2:36](Br)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[CH2:36]([O:33][CH:17]([C:18]1[S:19][C:20]([C:23]2[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:28]=2)=[CH:21][CH:22]=1)[CH2:16][CH2:15][C:13]1[CH:12]=[CH:11][C:3]([O:4][CH:5]([CH2:9][CH3:10])[C:6]([OH:8])=[O:7])=[C:2]([F:1])[CH:14]=1)[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

Participants

Reactant 3

HCID 7498Benzyl Bromide

HCID 24758Sodium hydride

HCID 25059981HCID 25059981, compound

Product 1

HCID 59180346HCID 59180346, compound

Procedure

2-(4-(3-(Benzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2-fluoro-phenoxy)butanoic acid is prepared from 2-(2-fluoro-4-(3-hydroxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)butanoic acid using 2.1 equivalents of sodium hydride and 2.1 equivalents of benzyl bromide according to general procedure H.

Sources & evidence

ORD record: ord-47e0b3b1a88e453b85d35c7fafb0e0b0
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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