反应详情

1-(4-Bromonaphthalen-1-yl)-2-diazoethanone (13.8 g) was dissolved in ethyl acetate (200 mL), and hydrobromic acid solution (8.4 mL, 5.7 M in acetic acid) was added at 0° C. Reaction mixture was stirred 15 minutes, NaHCO3 solution (100 mL) was added, and mixture was stirred 10 minutes. Ethyl acetate solution was extracted twice with NaHCO3 solution (50 mL), once with brine (50 mL), and evaporated under vacuum. The oil was dissolved in DCM and purified by chromatography (0-20% ethyl acetate:hexane), giving 2-bromo-1-(4-bromo-naphthalen-1-yl)-ethanone (6.67 g, 51%) as a tan solid.

1. customReaction mixture
2. stirringmixture was stirred 10 minutes
3. extractionEthyl acetate solution was extracted twice with NaHCO3 solution (50 mL), once with brine (50 mL)
4. customevaporated under vacuum
5. dissolutionThe oil was dissolved in DCM
6. custompurified by chromatography (0-20% ethyl acetate:hexane)