Triethylamine → HCID 57713832, compound

HRID 417890Notes

Reaction equation

HRID 417890 reaction equation
C([O:4][CH2:5][C:6]([C:13]#[C:14][C:15]1[C:23]2[C:22]([Cl:24])=[N:21][C:20]([NH2:25])=[N:19][C:18]=2[N:17]([CH2:26][C:27]2[C:32]([CH3:33])=[C:31]([O:34][CH3:35])[C:30]([CH3:36])=[CH:29][N:28]=2)[CH:16]=1)([OH:12])[CH2:7][O:8]C(=O)C)(=O)C.CCN(CC)CC>C1COCC1.CO>[NH2:25][C:20]1[N:21]=[C:22]([Cl:24])[C:23]2[C:15]([C:14]#[C:13][C:6]([OH:12])([CH2:7][OH:8])[CH2:5][OH:4])=[CH:16][N:17]([CH2:26][C:27]3[C:32]([CH3:33])=[C:31]([O:34][CH3:35])[C:30]([CH3:36])=[CH:29][N:28]=3)[C:18]=2[N:19]=1

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 57713846HCID 57713846, compound

Product 1

HCID 57713832HCID 57713832, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-((2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo [2,3-d]pyrimidin-5-yl)ethynyl)-2-hydroxypropane-1,3-diyl diacetate (see example 56) (60 mg) and Et3N (1 mL) in THF (1 mL) and MeOH (6 ml,) was heated in a microwave oven to 150° C. for 20 min. Concentration and preparative HPLC gave the title compound, as a solid. HPLC Rt =3.90 min.

Workup

  1. concentrationConcentration and preparative HPLC

Sources & evidence

ORD record
ord-b59f7f8685a84a26bb2b06df615dfd20
Source dataset
uspto-grants-2012_01
Patent number
US08093229B2

Reaction notes

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