反应详情

To a solution of 4-hydroxy-1-methyl piperidine (3.00 g, 26.1 mmol) and NMM (3.0 mL, 27.3 mmol) in DCM (50 mL) at 0° C. was added p-nitrophenyl chloroformate (5.51 g, 27.4 mmol). The reaction mixture was stirred at room temperature for 4 hours, and a cream precipitate gradually formed. The reaction mixture was filtered and the residue was washed with DCM (50 mL) to give 1-methylpiperidin-4-yl 4-nitrophenyl carbonate (7.24 g, 99%) as a cream solid.

1. customa cream precipitate gradually formed
2. filtrationThe reaction mixture was filtered
3. washthe residue was washed with DCM (50 mL)