反应详情

温度

100 °C

1-Methylhomopiperazine (2.00 g, 17.5 mmol) and DIPEA (3.0 mL, 18.4 mmol) were dissolved in DMF (25 mL). 2-bromethanol (1.3 mL, 18.4 mmol) was added slowly over 5 minutes. The reaction mixture was stirred at 100° C. for 2 hours and then at room temperature for 48 hours and then concentrated in vacuo. The residue was dissolved in EtOAc (−300 mL) and then washed sequentially with 1M aq Na2CO3 solution (5×200 mL), dried (MgSO4) and concentrated in vacuo to give 2-(4-methylhomopiperazin-1-yl)ethanol (2.77 g, 100%) as a brown oil which was used without further purification.

1. waitat room temperature for 48 hours
2. concentrationconcentrated in vacuo
3. dissolutionThe residue was dissolved in EtOAc (−300 mL)
4. washwashed sequentially with 1M aq Na2CO3 solution (5×200 mL)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo