反应详情

To a solution of Z-(L)Glu(OtBu)-OH (5 g) in DCM/THF (1:1, 42 ml) were added at RT HOBT (2.5 g) and EDCI (3.1 g). After 15 min stirring at RT, 1-ethoxycarbonylpiperazine (2.6 g) was added and the stirring was continued at RT overnight. 150 ml of EA and 60 ml of a NaHCO3 solution were added to the reaction mixture and the phases were separated. The org. phase was washed with an aq. NaHSO4 (1M) solution and with brine, dried over Na2SO4 and evaporated off. After HV drying, 7 g of the desired compound were obtained.

1. waitthe stirring was continued at RT overnight
2. customthe phases were separated
3. washphase was washed with an aq. NaHSO4 (1M) solution and with brine
4. dry with materialdried over Na2SO4
5. customevaporated off
6. customAfter HV drying