反应详情

温度

120 °C

2,5-Dimethylindole (300 mg) and 8-nitro-4-chloroquinoline (430 mg) were suspended in NMP (10 ml) containing 4M HCl in dioxane (2 drops) and maintained under a nitrogen atmosphere. The reaction was heated to 120° C. with stirring for 8 hours. When cooled, the mixture was basified with saturated sodium hydrogen carbonate solution and extracted into ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give an oil. The oil was purified by flash column chromatography using 2:1 isohexane/ethyl acetate as eluent to give the sub-title compound (560 mg).

1. temperaturemaintained under a nitrogen atmosphere
2. temperatureWhen cooled
3. extractionextracted into ethyl acetate
4. dry with materialdried (MgSO4)
5. customevaporated under reduced pressure
6. customto give an oil
7. customThe oil was purified by flash column chromatography