反应详情

温度

100 °C

1H-Indazol-4-amine (81 mg, 0.61 mmol) and methyl 3-iodobenzoate (160 mg, 0.61 mmol) were dissolved in DMF (1 mL) in a microwave tube. Copper (I) iodide (23 mg, 0.12 mmol), trans-N,N′-dimethyl-1,2-cyclohexanediamine (34 mg, 0.24 mmol) and potassium carbonate (169 mg, 1.22 mmol) were added and the mixture heated by microwave (250 W) at 100° C. for 20 minutes. The mixture was filtered through a cartridge, washing with DCM (5 mL) and the filtrate was evaporated to dryness and purified by mass-directed autopreparation. The appropriate fractions were evaporated, dissolved in DCM (10 mL), washed with aqueous sodium bicarbonate, and evaporated to give the title compound (32.7 mg).

1. filtrationThe mixture was filtered through a cartridge
2. washwashing with DCM (5 mL)
3. customthe filtrate was evaporated to dryness
4. custompurified by mass-directed autopreparation
5. customThe appropriate fractions were evaporated
6. dissolutiondissolved in DCM (10 mL)
7. washwashed with aqueous sodium bicarbonate
8. customevaporated