反应详情

A solution of fenbufen (214 mg, 0.8 mmol), HBTU (302 mg, 0.8 mmol), DIEA (1 mL, 0.8 mmol) and DMF (15 mL) was stirred. 4-azido-1-butanamine was added. TLC (acetone/n-hexane= 3/7) indicated the consumption of starting material (Rf=0.39) and the formation of the product (Rf=0.78). After stirring for 1 hr, the mixture was concentrated under high vacuum at 60° C. The residue was purified by flash chromatography using acetone: n-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg).

1. customthe consumption of starting material (Rf=0.39)
2. concentrationthe mixture was concentrated under high vacuum at 60° C
3. customThe residue was purified by flash chromatography
4. customn-hexane=3:7 as eluents to provide a snow-white solid in 77% yield (269 mg)