反应详情

1-Benzyl-4-chlorophthalazine (1.06 g, 4.18 mmol) and piperazine (1.82 g, 20.9 mmol) are added into a microwave vial, followed by NMP (5 ml) and triethylamine (6.62 ml, 12.5 mmol). The vial is sealed and irradiated in the microwave at 180° C. (high absorption setting) for 30 minutes. Dichloromethane (10 mL) is added to form a precipitate, which is washed with additional dichloromethane and dried under reduced pressure to afford the product as a white powder (745 mg, 58% yield).

1. customThe vial is sealed
2. customirradiated in the microwave at 180° C. (high absorption setting) for 30 minutes
3. customto form a precipitate, which
4. washis washed with additional dichloromethane
5. customdried under reduced pressure