4-Toluenesulfonyl chloride → HCID 86632381, compound

HRID 423451Notes

Reaction equation

HRID 423451 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][CH:17]=[CH:16][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:12][C@H:11]([CH2:13][OH:14])[O:10][C:9]1=[O:15].C(N([CH2:25][CH3:26])CC)C.[C:27]1(C)[CH:32]=C[C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1>ClCCl>[C:25]1([CH3:26])[C:30]([S:33]([O:14][CH2:13][C@@H:11]2[O:10][C:9](=[O:15])[N:8]([CH2:7][CH2:6][O:5][C:4]3[CH:16]=[CH:17][CH:18]=[CH:19][C:3]=3[O:2][CH3:1])[CH2:12]2)(=[O:35])=[O:34])=[CH:29][CH:28]=[CH:27][CH:32]=1

Participants

5

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 66677026HCID 66677026, compound

Product 1

HCID 86632381HCID 86632381, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using dichloromethane solution of the compound of formula 2 prepared in Example 2 42.7 g (0.16 mol), triethylamine 24.3 g (0.24 mol) and p-toluenesulfonyl chloride 33.6 g (0.176 mol), the procedures as described in Example 7 were carried out to obtain the targeted product.

Workup

  1. customto obtain the targeted product

Sources & evidence

ORD record
ord-6fe1c95a3bd3481d8c852f4cdd46897e
Source dataset
uspto-grants-2012_01
Patent number
US08101781B2

Reaction notes

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