Triethylamine → HCID 58807439, compound

HRID 424299Notes

Reaction equation

HRID 424299 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][P:7](=[O:14])([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:24](Cl)(=[O:28])[C:25]([CH3:27])=[CH2:26]>C1(C)C=CC=CC=1>[C:24]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][P:7](=[O:14])([O:8][CH2:9][CH3:10])[O:11][CH2:12][CH3:13])=[CH:15][CH:16]=1)(=[O:28])[C:25]([CH3:27])=[CH2:26]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 88358Diethyl p-aminobenzylphosphonate

Product 1

HCID 58807439HCID 58807439, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By the same procedure as described in example 1, diethyl 4-(amino)benzylphosphonate (1.94 g; 8 mmoles), triethylamine (0.87 g; 8.6 mmoles), and methacryloyl chloride (0.9 g; 8.6 mmoles) in toluene (9 ml) afford diethyl 4-(methacrylamido)benzylphosphonate as a slight yellow solid (2.3 g; yield 92%).

Sources & evidence

ORD record
ord-54df1c15037d44b594d6465ad395433a
Source dataset
uspto-grants-2012_01
Patent number
US08105689B2

Reaction notes

Loading…