Oxalyl chloride → HCID 59212307, compound

HRID 424711Notes

Reaction equation

HRID 424711 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[CH:5]=[C:4]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=2[CH3:22])[C:16]([NH2:18])=[O:17])[C:3]1=[O:23].C(Cl)(=O)[C:25](Cl)=[O:26]>ClCCCl>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[CH:5]=[C:4]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=2[CH3:22])[C:16]([N:18]=[C:25]=[O:26])=[O:17])[C:3]1=[O:23]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 59212543HCID 59212543, compound

Product 1

HCID 59212307HCID 59212307, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

3-(1,7-Dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylbenzamide 30 (310 mg, 1 mmol) is heated with oxalyl chloride (1 mL) in 1,2-dichloroethane (2 mL) at reflux for 2 h. Solvent is evaporated to give 31 as a white solid which is used without purification.

Workup

  1. temperatureat reflux for 2 h
  2. customSolvent is evaporated

Sources & evidence

ORD record
ord-ed98fd2868234a68a0688eeaca14c296
Source dataset
uspto-grants-2012_01
Patent number
US08106068B2

Reaction notes

Loading…