Pyrrolidine → HCID 57867958, compound

HRID 425990Notes

Reaction equation

HRID 425990 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1([C:15]([O-:17])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1.Cl.C(N=C=NCCCN(C)C)C.ON1C2C=CC=CC=2N=N1>C(Cl)Cl>[N:18]1([C:15]([C:9]2([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[O:17])[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

6

Reactant 4

HCID 31268PyrrolidineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 7169935HCID 7169935, compound

Product 1

HCID 57867958HCID 57867958, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[(tert-Butoxycarbonyl)amino]cyclohexancarboxylate, pyrrolidine, 1-ethyl-3-[3-(N,N-dimethylamino)propyl]carbodiimide hydrochloride and 1-hydroxybenzotriazole were allowed to undergo the reaction at room temperature in methylene chloride. By post-treating the reaction liquid, tert-butyl [1-(pyrrolidin-1-ylcarbonyl)cyclohexyl]carbamate was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-d6073781b4c145c988f32fadc54773fa
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

Loading…