Ammonia → HCID 57614568, compound

HRID 426000Notes

Reaction equation

HRID 426000 reaction equation
C(Cl)(=O)C(Cl)=O.[C:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[C:13]([F:20])[CH:12]=1)([CH3:10])([CH3:9])[CH3:8].[NH3:21]>C1COCC1>[C:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH2:21])=[O:16])=[C:13]([F:20])[CH:12]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 20627849HCID 20627849, compound

Product 1

HCID 57614568HCID 57614568, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Oxalyl chloride was added to a THF solution of 4-tert-butyl-2-fluorobenzoic acid and stirred for 1 hour, and aqueous ammonia was added to this. By post-treating the reaction liquid, 4-tert-butyl-2-fluorobenzamide was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-ca5c45644e2b42a3aceae201aee18af3
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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