反应详情

To a mixture of 5-isopropyl-6-(3′-cyano-5′-methylbenzoyl)-2,4-pyrimidinedione (1.19 g, 4 mmol), 2,4-dichloro-6-chloromethyl-pyrimidine (790 mg, 4 mmol), anhydrous powdered potassium carbonate (552 mg, 4 mmol), and lithium iodide (536 mg, 4 mmol), was added DMF (20 ml). The mixture was stirred at room temperature for overnight and evaporated in vacuo. The residue was then purified by silica gel column chromatography (eluent, EA:hexane (1:2)) to afford 476 mg (26%) of 3-[3-(2,6-dichloro-pyrimidin-4-ylmethyl)-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl]-5-methyl-benzonitrile as a pale yellow foam.

1. customevaporated in vacuo
2. customThe residue was then purified by silica gel column chromatography (eluent, EA:hexane (1:2))