反应详情

To a mixture of 1.00 g of 1-[2-(2-naphthyl)-2-hydroxyethyl]imidazole, 0.81 g of p-chlorophenol and 0.92 g of diethyl azodicarboxylate in 20 ml. of dry tetrahydrofuran at room temperature was added 1.65 g of triphenylphosphine (with stirring). The resulting yellow solution was stirred overnight, the solvent evaporated and the residual oil dissolved in ether. The hydrochloride salt of the product was precipitated as a gum by dropwise addition of ethereal hydrogen chloride, and crystallized from ethyl acetate to give 1[2-(2-naphthyl)-2-(4-chlorophenoxy)ethyl]imidazole hydrochloride.

1. customthe solvent evaporated
2. dissolutionthe residual oil dissolved in ether
3. customThe hydrochloride salt of the product was precipitated as a gum by dropwise addition of ethereal hydrogen chloride
4. customcrystallized from ethyl acetate