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HRID427303

反应详情

EQUATION

反应方程式

HRID 427303 的结构方程式

REACTANTS

反应物

2
结构：Cn1ncc(C#N)c1N
HCID219740

5-amino-1-methyl-1H-pyrazole-4-carbonitrile

C5H6N4

结构：COc1ccc(C(=O)Oc2ccc([N+](=O)[O-])cc2)c2sc(N3CCCCC3)nc12
HCID69691118

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)Nc2c(C#N)cnn2C)c2sc(N3CCCCC3)nc12
HCID10200779

未命名化合物

收率 75.5%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：C[Si](C)(C)[N-][Si](C)(C)C.[Na+]
溶剂HCID2724254

Sodium bis(trimethylsilyl)amide

C6H18NNaSi2

PROCEDURE

实验过程

Starting from 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (125 mg) in dimethyl formamide (10 ml), sodium hexamethyldisilazide in tetrahydrofuran (1.1 ml, 1.0 M), and 4-methoxy-2-(piperidin-1-yl)benzothiazole-7-carboxylic acid 4-nitrophenyl ester (210 mg). Purification by flash chromatography (eluent 5% methanol in dichloromethane) followed by trituration with ethyl acetate yielded the title compound as an off-white solid (152 mg). TLC Rf 0.48 (ethyl acetate); Mpt 290-291° C.

WORKUP

后处理

  1. customPurification by flash chromatography (eluent 5% methanol in dichloromethane)