反应详情

5,6-diaminonicotinamide (10 g, 66 mmol), chloroacetone (6.1 g, 66 mmol) and sodium bicarbonate (11.2 g, 132 mmol) were added to dimethylformamide (200 ml) and the mixture was stirred for 72 h. at room temperature. Most of the solvent was evaporated under reduced pressure and methanesulfonic acid (6 g, 63 mmol) was added. More solvent was evaporated under reduced pressure and ethanol was added to the residue. Upon warming the mixture to 60° C. the product crysstallized as salt and was filtred off to give 6 g (32%) of the title compound.

1. additionwas added
2. customMore solvent was evaporated under reduced pressure and ethanol
3. additionwas added to the residue
4. temperatureUpon warming the mixture to 60° C. the product