Diethyl Ether → HCID 131722973, compound

HRID 428811Notes

Reaction equation

HRID 428811 reaction equation
[CH3:1][Si:2]([CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[N:23][OH:24])[C:20](=[O:22])[CH3:21])=[CH:15][CH:14]=1)([CH3:10])[C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][CH:4]=1.[CH2:25](Br)[CH3:26].C(=O)([O-])[O-].[K+].[K+].C(OCC)C>CN(C)C=O>[CH2:25]([O:24][N:23]=[C:19]([C:16]1[CH:17]=[CH:18][C:13]([O:12][CH2:11][Si:2]([CH3:10])([CH3:1])[C:3]2[CH:8]=[CH:7][C:6]([F:9])=[CH:5][CH:4]=2)=[CH:14][CH:15]=1)[C:20](=[O:22])[CH3:21])[CH3:26]

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 88213798HCID 88213798, compound

Product 1

HCID 131722973HCID 131722973, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

13.8 g of 1-(4-[{dimethyl-(4-fluorophenyl)-silyl}methoxy]phenyl)-propane-1,2-dione-1-oxime, 4 ml of ethyl bromide and 9 g of potassium carbonate are stirred in 150 ml of dimethylformamide for 2 hours at room temperature. 200 ml of diethyl ether are added to the reaction mixture, which is then washed with water and saturated sodium chloride solution; the organic phase is dried and the solvent is evaporated off to yield the title product in the form of an oil.

Workup

  1. washis then washed with water and saturated sodium chloride solution
  2. customthe organic phase is dried
  3. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-67a91b269c714940988eb6d62bbbfa0a
Source dataset
uspto-grants-2001_11
Patent number
US06313344B1

Reaction notes

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